Laboratory of Metabolism of Bioactive Lipids

The goal of the laboratory is to elucidate how metabolites influence organ function, nutrient sensing, inter-organ communication, and liver and adipose tissue physiology. Current projects investigate complications of type 2 diabetes, adipose tissue metabolism, heart failure, various cancers, and cachexia, spanning the fields of physiology, chemistry, and bioinformatics. Core expertise includes in vivo experiments with mice (infusions, clamps, dietary experiments) and cell culture experiments (subcellular metabolomics, fluxomics). The laboratory specializes in the analysis of polar metabolites, simple and complex lipids, and lipid mediators such as FAHFAs, using advanced mass spectrometry-based methods. The workflows integrate different omics techniques, including metabolomics, lipidomics, transcriptomics and metabolic flux analysis, supported by specialized bioinformatics tools developed in the lab.