Laboratory of Metabolism of Bioactive Lipids

Laboratory of Metabolism of Bioactive Lipids - bg 3

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Laboratory of Metabolism of Bioactive Lipids -

About the Laboratory

The goal of the laboratory is to elucidate how metabolites influence organ function, nutrient sensing, inter-organ communication, and liver and adipose tissue physiology. Current projects investigate complications of type 2 diabetes, adipose tissue metabolism, heart failure, various cancers, and cachexia, spanning the fields of physiology, chemistry, and bioinformatics. Core expertise includes in vivo experiments with mice (infusions, clamps, dietary experiments) and cell culture experiments (subcellular metabolomics, fluxomics). The laboratory specializes in the analysis of polar metabolites, simple and complex lipids, and lipid mediators such as FAHFAs, using advanced mass spectrometry-based methods. The workflows integrate different omics techniques, including metabolomics, lipidomics, transcriptomics and metabolic flux analysis, supported by specialized bioinformatics tools developed in the lab. 

Achievements

Ondrej Kuda, Head of Laboratory of Metabolism of Bioactive Lipids at the Institute of Physiology of the CAS, received the Prize of the Minister of Education for outstanding results in research, experimental development and innovation on 20 November 2023. The prize was awarded for the results of research on the new signaling lipid molecules that suppress inflammation and improve glucose metabolism in patients with diabetes.

Laboratory of Metabolism of Bioactive Lipids - nz9 1274

Veronika Paluchova was awarded Barrande Fellowship Program 2020 – Internship grant in category Life Sciences and Medicine (Evaluation of oxidative stress biomarkers in mouse models with genetically altered Peroxiredoxin 6.)

 

Our laboratory has been awarded the grant GA20-00317S New metabolic pathway in the synthesis of anti-diabetic lipokines (2020-2022).

 

Ondrej Kuda has been awarded Lumina Quaeruntur praemium.

Laboratory of Metabolism of Bioactive Lipids - be8a2326

Publications

Publication year

Prestigious publication

Search publication

Riečan; Martin - Domanská; Veronika - Lupu; C. - Patel; M. - Vondráčková; Michaela - Rossmeisl; Martin - Saghatelian; A. - Lupu; F. - Kuda; Ondřej Tissue-specific sex-dependent difference in the metabolism of fatty acid esters of hydroxy fatty acids. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 2024; 1869(8); 159543.

IF = 3.9

Parchem; K. - Letsiou; S. - Petan; T. - Oskolkova; O. - Medina; I. - Kuda; Ondřej - O'Donnell; V. B. - Nicolaou; A. - Fedorova; M. - Bochkov; V. - Gladine; C. Oxylipin profiling for clinical research: Current status and future perspectives. Progress in Lipid Research. 2024; 95(July); 101276.

IF = 14.0

Jadhav; Sukanya B. - Vondráčková; Michaela - Potomova; Petra - Sandoval-Acuna; Cristian - Šmigová; J. - Klanicova; Kristyna - Rosel; D. - Brabek; J. - Štursa; Jan - Werner; Lukáš - Truksa; Jaroslav NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation. Frontiers in Pharmacology. 2024; 15(JUN 25 2024); 1422369.

IF = 4.4

Kasperová; B. J. - Mráz; M. - Svoboda; P. - Hlaváček; D. - Kratochvílová; H. - Modos; I. - Vrzáčková; N. - Ivák; P. - Janovská; Petra - Kobets; Tetyana - Mahrík; J. - Riečan; Martin - Steiner Mrázová; Lenka - Stránecký; V. - Netuka; I. - Čajka; Tomáš - Kuda; Ondřej - Melenovský; V. - Štemberková-Hubáčková; S. - Haluzík; M. Sodium-glucose cotransporter 2 inhibitors induce anti-inflammatory and anti-ferroptotic shift in epicardial adipose tissue of subjects with severe heart failure. Cardiovascular Diabetology. 2024; 23(1); 223.

IF = 8.5

Brejchová; Jana - Brejchová; Kristýna - Kuda; Ondřej Metabolic Pathways of Acylcarnitine Synthesis. Physiological Research. 2024; 73(Suppl.1); S153-S163.

IF = 1.9

Song; J. - Duivenvoorde; L. P. M. - Grefte; S. - Kuda; Ondřej - Martínez-Ramírez; Felipe - van der Stelt; I. - Mastorakou; D. - van Schothorst; E. M. - Keijer; J. Normobaric hypoxia shows enhanced FOXO1 signaling in obese mouse gastrocnemius muscle linked to metabolism and muscle structure and neuromuscular innervation. Pflugers Archiv - European Journal of Physiology. 2023; 475(11); 1265-1281.

IF = 2.9

Photogallery

People

Head of Laboratory

Head of Laboratory
Tel: 2448
Email: ondrej.kuda@fgu.cas.cz

Deputy Head of Laboratory

Laboratory staff

Associate scientist
Tel: 2448
Email: kristyna.brejchova@fgu.cas.cz
Lab technician
Tel: 2527
Email: monika.krakovkova@fgu.cas.cz
Postdoctoral fellow
Tel: 2527
Email: dovile.milonaityte@fgu.cas.cz
Graduate student
Tel: 2527
Email: martin.riecan@fgu.cas.cz
Research assistant
Tel: 2527
Email: martina.rombaldova@fgu.cas.cz
Research assistant
Tel: 2701
Email: jakub.schimmer@fgu.cas.cz
Technical worker
Tel: 2701
Email: andrea.vankova@fgu.cas.cz
Graduate student
Tel: 2527
Email: michaela.vondrackova@fgu.cas.cz