Laboratory of Mitochondrial Physiology

Content of this page

About the Laboratory

Mitochondrial metabolism involves canonical energy production as well as non-canonical functions, specifically metabolic signaling, redox signaling, or epigenetic regulation. Both canonical and non-canonical mitochondrial functions are tissue-specific, activated under various stress stimuli, or nutrient starvation. Our projects focus on mitochondrial metabolic pathways that can induce complex changes in redox signaling, mitochondrial and cellular metabolic landscape, and associate with pathological states, such as type 2 diabetes or cancer progression. Our main projects are:

Redox biology of insulin secretion and in development of type 2 diabetes
Mitochondrial ultramorphology
Specificities of cancer metabolism
Development of GLP-1-conjugated nanoparticles for β-cell magnetic resonance imaging

Projects

Redox regulations in physiological and pathological processes of cell and organism

Specific mitochondrial metabolism in cancer cells

Mitochondrial network and mtDNA organization, and genetic manipulations of mtDNA

Publications

Zhang; KZ. - Ježek; Petr Mitochondrial dynamics: updates and perspectives. Scientific Reports. 2024; 14(1); 9936.

IF = 3.8

Shapoval; Oleksandr - Patsula; Vitalii - Větvička; D. - Engstová; Hana - Oleksa; Viktoriia - Kabešová; M. - Vasylyshyn; Taras - Poučková; P. - Horák; Daniel Temoporfin-conjugated PEGylated poly(N;N-dimethylacrylamide)-coated upconversion colloid for NIR-induced photodynamic therapy of pancreatic cancer. Biomacromolecules. 2024; 25(9); 5771-5785.

IF = 5.5

Jabůrek; Martin - Klöppel; Eduardo - Průchová; Pavla - Mozheitova; Olexandra - Tauber; Jan - Engstová; Hana - Ježek; Petr Mitochondria to plasma membrane redox signaling is essential for fatty acid ?-oxidation-driven insulin secretion. Redox Biology. 2024; 75(September); 103283.

IF = 10.7

Ježek; Petr - Dlasková; Andrea - Engstová; Hana - Špačková; Jitka - Tauber; Jan - Průchová; Pavla - Klöppel; Eduardo - Mozheitova; Olexandra - Jabůrek; Martin Mitochondrial Physiology of Cellular Redox Regulations. Physiological Research. 2024; 73(Suppl.1); S217-S242.

IF = 1.9

Klöppel; Eduardo - Cruz; L. L. - Prado-Souza; L. F. L. - Eckhardt; Adam - Corrente; J. E. - dos Santos; D. C. - Justulin; L. A. - Rodrigues; T. - Volpato; G. T. - Damasceno; D. C. Insulin signaling and mitochondrial phenotype of skeletal muscle are programmed in utero by maternal diabetes. Molecular and Cellular Endocrinology. 2024; 588(1 July); 112199.

IF = 3.8

Gotvaldová; Klára - Špačková; Jitka - Novotný; Jiří - Baslarová; Kamila - Ježek; Petr - Rossmeislová; L. - Gojda; J. - Smolková; Katarína BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria. Cancer & Metabolism. 2024; 12(1); 10.

IF = 6.0