Laboratory of Neurophysiology of Memory

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About the Laboratory

Our Laboratory has been involved in learning, memory, and cognitive function studies. For instance, spatial orientation is now considered a type of so-called declarative memory (the ability to remember facts and events). This capability is dominantly affected in Alzheimer’s disease and other dementias, obsessive-compulsive disorder, or schizophrenia. These are conditions for which we do not know details of their physiology, so we actually treat only symptoms but not causes. Using neuroanatomical, neuropharmacological, cellular, molecular, and behavioral approaches, we investigate brain function in relation to behavior, both in health and disease. In an intense collaboration, we also work on the development of novel therapeutics focused on brain diseases.

EXTERNAL WEBSITE OF THE LABORATORY

Projects

Molecular and in vivo imaging, immediate-early genes, cognitive coordination and psychosis

Neuropharmacological studies, animal models of brain disorders and new therapeutics

Study of cognitive functions in humans, spatial navigation and its impairment

Integration of molecular, cellular and systems approaches in study of cognitive functions

Achievements

Publications

Abad; C. - Musilová; I. - Cífková; E. - Portillo; R. - Kumnova; F. - Karahoda; R. - Štěrba; M. - Lísa; M. - Kacerovský; M. - Stráník; J. - Stuchlík; Aleš - Štaud; F. Impact of intraamniotic inflammation on tryptophan metabolism in the placenta-fetal brain axis in rats. Reproduction. 2025; 169(5); e240378.

IF = 3.7

Vosála; O. - Šmídová; B. - Novák; J. - Svoboda; Jan - Petrásek; T. - Vojtěchová; I. - Macháček; T. No evidence of Alzheimer’s disease pathology in mice infected with Toxocara canis. Parasite. 2025; 32(9 April); 24.

IF = 2.4

Ahmed; A. A. A. - Alegret; N. - Almeida; B. - Alvarez-Puebla; R. - Andrews; A. M. - Ballerini; L. - Barrios-Capuchino; J. J. - Becker; C. - Blick; R. H. - Bonakdar; S. - Chakraborty; I. - Chen; X. - Cheon; J. - Chilla; G. - Coelho Conceicao; A. L. - Delehanty; J. - Dulle; M. - Efros; A. L. - Epple; M. - Fedyk; M. - Feliu; N. - Feng; M. - Fernandez-Chacon; R. - Fernandez-Cuesta; I. - Fertig; N. - Foerster; S. - Garrido; J. A. - George; M. - Guse; A. H. - Patrono; Enrico Interfacing with the Brain: How Nanotechnology Can Contribute. ACS Nano. 2025; 19(11); 10630-10717.

IF = 16.0

Rudolfová; V. - Antošová; E. - Petrásek; T. - Valeš; Karel - Landová; E. - Frynta; D. - Nekovářová; Tereza Consistency of cognitive performance in spatial navigation and its link to and boldness in rats. Behavioural Processes. 2025; 228(May); 105205.

IF = 1.5

Dvořáková; Tereza - Lobellová; Veronika - Manubens; P. - Sanchez-Jimenez; A. - Villacorta-Atienza; J. A. - Stuchlík; Aleš - Levčík; David Spatial prediction of dynamic interactions in rats. PLoS ONE. 2025; 20(2); e0319101.

IF = 2.6

Diez-Hermano; S. - Aparicio-Rodriguez; G. - Manubens; P. - Sanchez-Jimenez; A. - Calvo-Tapia; C. - Levčík; David - Villacorta-Atienza; J. A. Minimal Neural Network Conditions for Encoding Future Interactions. International Journal of Neural Systems. 2025; 35(04); 2550016.

IF = 6.4