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Cutting-edge science for health

Laboratory of Metabolism of Bioactive Lipids

Laboratory of Metabolism of Bioactive Lipids Metabolism of bioactive lipids

The Laboratory focuses on the analysis of lipid mediators (eicosanoids, docosanoids, endocannabinoids) using the UPLC-MS/MS method, in particular to identify the source of production of various mediators and their effect on metabolism and immune cells (i.e. adipocytes vs. macrophages). Currently, the lab is exploring new anti-diabetic lipids, fatty acid esters of hydroxy fatty acids and lipid-related metabolic pathways using stable isotopes and LIMeX platform.

We are always interested to hear from prospective (MSc, PhD or postdoc) candidates. Please submit a short personal statement detailing your research interests and qualifications, and a CV by email, RE: "metabolomics".

GTTAtlas GTTAtlas - interactive metabolomics and lipidomics atlas of mouse tissues during oral glucose tolerance test (OGTT).

MetaboAtlas21 MetaboAtlas21 - a comprehensive atlas of the mouse metabolome and lipidome.


Omega-3 polyunsaturated fatty acids

Naturally occurring long-chain omega-3 PUFA, namely eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3) exert multiple biological effects... More

Branched fatty acid esters of hydroxy fatty acids (FAHFA)

White adipose tissue (WAT) is a complex endocrine organ and its low-grade inflammation in obesity contributes to the development of metabolic disorders. In 2014, a class of WAT-born lipid mediators - fatty acid esters of hydroxy fatty acids (FAHFA) was discovered. FAHFAs are endogenous lipids with anti-inflammatory and anti-diabetic properties, including the enhancement of glucose tolerance, and insulin and glucagon-like peptide 1 (GLP-1) secretion while reducing inflammatory responses [1-5]. More

Open science

Our lab participates in OPEN SCIENCE initiative and hosts high school students with their project in metabolomics. More

Chemoinformatics resources

We run local instances of several services focused on Metabolomics, Lipidomics, Statistical analysis and Chemometrics. As the hardware resources are limited, these tools are available only within campus LAN. More



Sistilli; Gabriella - Kalendová; Veronika - Čajka; Tomáš - Irodenko; Ilaria - Bardová; Kristina - Oseeva; Marina - Žáček; P. - Kroupová; Petra - Horáková; Olga - Lackner; K. - Gastaldelli; A. - Kuda; Ondřej - Kopecký; Jan - Rossmeisl; Martin . Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity . Nutrients. 2021; 13(2)); 437 . IF = 5.717 [ASEP] [ doi ]
Lopes; Magno Alves - Brejchová; Kristýna - Riečan; Martin - Nováková; Michaela - Rossmeisl; Martin - Čajka; Tomáš - Kuda; Ondřej . Metabolomics atlas of oral 13C-glucose tolerance test in mice . Cell Reports. 2021; 37(2)); 109833 . IF = 9.423 [ASEP] [ doi ]
Leal; L. G. - Lopes; Magno Alves - Peres; S. B. - Batista; M. L.; Jr. Exercise Training as Therapeutic Approach in Cancer Cachexia: A Review of Potential Anti-inflammatory Effect on Muscle Wasting . Frontiers in physiology. 2021; 11(Feb 4)); 570170 . IF = 4.566 [ASEP] [ doi ]
Jacome-Sosa; M. - Miao; Z.-F. - Peche; V. S. - Morris; E. F. - Narendran; R. - Pietka; K. M. - Samovski; D. - Lo; H.-Y. G. - Pietka; T. - Varro; A. - Love-Gregory; L. - Goldenring; J. R. - Kuda; Ondřej - Gamanzon; E. R. - Mills; J. C. - Abumrad; N. A. CD36 maintains the gastric mucosa and associates with gastric disease . Communications Biology. 2021; 4(1)); 1247 . IF = 6.268 [ASEP] [ doi ]
Fisk; H. L. - Childs; C. E. - Miles; E. A. - Ayres; R. - Noakes; P. S. - Paras-Chaves; C. - Kuda; Ondřej - Kopecký; Jan - Antoun; E. - Lillycrop; K. A. - Calder; P. C. Dysregulation of endocannabinoid concentrations in human subcutaneous adipose tissue in obesity and modulation by omega-3 polyunsaturated fatty acids . Clinical science. 2021; 135(1); 185-200 . IF = 6.124 [ASEP] [ doi ]

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Ondrej Kuda, Ph.D.
Head of the Laboratory
Kristyna Brejchova, Ph.D.
Magno Alves Lopes, Ph.D.
Postdoctoral Fellow
Ing. Veronika Paluchova
Postgradual Student
Mgr. Martin Riečan
Postgradual Student
Felipe Martínez Ramírez, MSc.
postgradual student

Mgr. Marie Březinová
Postgradual Student (maternity leave)
Mgr. Martina Rombaldová, Ph.D.
(maternity leave)
Mgr. Marina Oseeva
PhD student abroad