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Laboratory of Molecular Neurobiology

Laboratory of Molecular Neurobiology Left: GFP-labeled hippocampal granule cells (green), in utero electroporated. Middle: Dendrites (arrows) and dendritic spines (inset) of cortical pyramidal neurons (red) and their 3D model. Right: NFL antibody-stained peripheral neurons in E11.5 embryos.

Defects in signaling cascades are considered to contribute to many neurodevelopmental and neurodegenerative disorders, but the exact molecular mechanisms underlying the onset of these diseases are so far largely unknown. Using mouse models and primary neuron cultures, we focus on identification of genes, molecular mechanism and signaling cascades that regulate neuron polarization, axonal/dendritic growth and guidance in the developing nervous system, and their deregulation that leads to neurodevelopmental disorders as autism spectrum disorders, epilepsy or schizophrenia.

Our work focuses on:

  • the function of microtubule associated proteins of CRMP family and their isoforms in neural development
  • regulation of CRMP isoforms by prolyl isomerases during growth and guidance of axons/dendrites
  • the efect of tubulin pottranslational modifications and microtubule associated proteins on microtubule dynamics and cortical development in vitro and in vivo



Chvojka; J. - Procházková; N. - Řehořová; M. - Kudláček; J. - Kylarová; S. - Králiková; M. - Buran; Peter - Weissová; Romana - Balaštík; Martin - Jefferys; J. G. R. - Novák; O. - Jiruška; P. Mouse model of focal cortical dysplasia type II generates a wide spectrum of high-frequency activities . Neurobiology of Disease. 2024; 190(January); 106383 . IF = 6.1 [ASEP] [ doi ]
Cheema; Marie Munawar - Kotrbová Macáková; Zuzana - Hrčka Krausová; Barbora - Adla; Santosh Kumar - Slavíková; Barbora - Chodounská; Hana - Kratochvíl; Miroslav - Vondrášek; Jiří - Sedlák; David - Balaštík; Martin - Kudová; Eva . 5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia . Journal of Steroid Biochemistry and Molecular Biology. 2024; 239(May); 106464 . IF = 4.1 [ASEP] [ doi ]
Havelka; D. - Zhernov; Ilia - Teplan; M. - Lánský; Zdeněk - Chafai; Djamel Eddine - Cifra; M. Lab-on-chip microscope platform for electro-manipulation of a dense microtubules network . Scientific Reports. 2022; 12(1)); 2462 . IF = 4.6 [ASEP] [ doi ]
Průša; J. - Taha Ayoub; A. - Chafai; Djamel Eddine - Havelka; D. - Cifra; M. Electro-opening of a microtubule lattice in silico . Computational and Structural Biotechnology Journal. 2021; 19(Mar 4); 1488-1496 . IF = 6.155 [ASEP] [ doi ]
Maimon; R. - Ankol; L. - Pery; T. G. - Altman; T. - Ionescu; A. - Weissová; Romana - Ostrovsky; M. - Tank; E. - Alexandra; G. - Shelestovich; N. - Opatowsky; Y. - Dori; A. - Barmada; S. - Balaštík; Martin - Perlson; E. A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis . EMBO Journal. 2021; 40(17)); e107586 . IF = 13.783 [ASEP] [ doi ]

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  Martin Balaštík, Ph.D.
Head of the Laboratory
  Mgr. Romana Weissová
PhD Student/Deputy Head of the Laboratory

Mgr. Lenka Polidarova, Ph.D. 

Postdoctoral Fellow


Mgr. Barbora Pukajová

PhD Student


Mgr. Michaela Rusková

PhD Student


MSc. Maria Jose Ruiz Estrada

PhD Student


Bc. Polina Belyaeva

MSc Student



Jakub Ziak, MD, Ph.D. 

postdoc, Johns Hopkins Uni., Baltimore, USA 

Ing. Djamel Eddine Chafai, Ph.D. 

Assistant Professor, Kanazawa Uni., Japan