Laboratory of Developmental Epileptology

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Laboratory of Developmental Epileptology - stazeny soubor 5

About the Laboratory

The research at our Laboratory focuses on the pathophysiology of epilepsy and epileptic seizures in adulthood and particularly in the developing brain. In our research we are utilizing modern electrophysiological, imaging, biochemical and pharmacological techniques. To elucidate the cellular and network mechanisms involved in epilepsy and to increase the translational potential of new observations we are using extensively chronic models of acquired epilepsy and also genetic models and also collaborate with leading epilepsy centres.

 

     Pro náš výzkum požíváme interdisciplinární přístup zahrnující postupy molekulární biologie, neuropatologie, elektrofyziologie i behaviorální metody.

Our primary research topics are:

  • Consequences of brain injury during early stages of the brain development
  • Mechanisms responsible for seizure initiation and termination.
  • Impact of seizures on the developing brain
  • Development of new diagnostic techniques of epilepsy
  • Cognitive and behavioural consequences of epilepsy
  • The role of oxidative stress in pathogenesis of epilepsy and seizures during the development
  • Impact of antiepileptic therapy of the brain development
  • Age-specific mechanisms of seizure initiation and propagation

Achievements

Epileptology European Award 2016 was awarded prof. Pavel Mareš.

The European Epileptology Award is awarded every two years by the ILAE Commission on European Affairs (CEA) to European epileptologists in recognition of their outstanding contributions to European epileptology. It´s awarded to one clinical and one experimental epileptologist. Award-winning clinical epileptologist is prof. Federico Vigevano (Italy).

19.3. 2014

Centrum pro epilepsie Motol (doc. Marusič, doc. Kršek)

Fakulta elektrotechnická ČVUT (doc. Čmejla, doc. Lhotská, Ing. Klíma)

Ústav informatiky AV ČR (dr. Paluš, dr. Hlinka)

Ústřední vojenská nemocnice (prof. Beneš, dr. Vaněk)

ISARG Prague

Mayo Clinic, USA (prof. Worrell)

University of Birmingham, UK (prof. Jefferys)

Technische Universität Berlin (prof. Schoell)

Institute fo Neurophysiology, Charite, Berlin (Assoc. Prof. Kovacs, Prof. Heinemann)

The Chaim Sheba Medical Center (Dr. Maggio)

University of Eastern Finland (prof. Pitkanen)

David Geffen School of Medicine at UCLA, USA (prof. Wasterlain, prof. Sankar)

Center for Research and Advanced Studies, Mexico (dr. Rocha)

Institute of Neurobiology, Bulgarian Academy of Sciences (assoc.prof.Tchekalarova)

Publications

Danačíková; Šárka - Straka; B. - Daněk; Jan - Kořínek; V. - Otáhal; Jakub In vitro human cell culture models in a bench-to-bedside approach to epilepsy. Epilepsia Open. 2024; 9(3); 865-890.

IF = 2.8

Tefr Faridová; A. - Heřman; H. - Danačíková; Šárka - Svoboda; Jan - Otáhal; Jakub Serum biomarkers of hypoxic-ischemic brain injury. Physiological Research. 2023; 72(Suppl.5); S461-S474.

IF = 2.1

Al-Redouan; A. - Salaj; M. - Kubová; Hana - Druga; Rastislav Compartmental neuronal degeneration in the ventral striatum induced by status epilepticus in young rats’ brain in comparison with adults. International Journal of Developmental Neuroscience. 2024; 84(4); 328-341.

IF = 1.7

Rehák Bučková; Barbora - Kala; David - Kořenek; Jakub - Matušková; V. - Kumpošt; Vojtěch - Svobodová; L. - Otáhal; Jakub - Škoch; A. - Šulc; V. - Olšerová; A. - Vyhnálek; M. - Janský; P. - Tomek; A. - Marusič; P. - Jiruška; P. - Hlinka; Jaroslav Structural connectivity-based predictors of cognitive impairment in stroke patients attributable to aging. PLoS ONE. 2023; 18(4)); e0280892.

IF = 3.7

Pokošová; P. - Kala; David - Šanda; J. - Ježdík; P. - Prysiazhniuk; Y. - Faridová; A. - Jahodová; A. - Bělohlávková; A. - Kalina; A. - Holubová; Z. - Jurášek; B. - Kynčl; M. - Otáhal; Jakub Magnetic resonance imaging techniques for indirect assessment of myelin content in the brain using standard T1w and T2w MRI sequences and postprocessing analysis. Physiological Research. 2023; 72(Suppl.5); S573-S585.

IF = 2.1

Kubová; Hana - Mikulecká; Anna - Mareš; Pavel The outcome of early life status epilepticus-lessons from laboratory animals. Epilepsia Open. 2023; 8(Suppl.1); S90-S109.

IF = 3.0

People

Head of Laboratory

Vedoucí oddělení
Tel: 2565
Email: hana.kubova@fgu.cas.cz

Deputy Head of Laboratory

Zástupce vedoucího
Tel: 2813
Email: jakub.otahal@fgu.cas.cz

Laboratory staff

Laborantka
Tel: 2565
Email: blanka.cejkova@fgu.cas.cz
Odborný pracovník SŠ, VOŠ - laborantka
Tel: 2739
Email: alika.chernova@fgu.cas.cz
Tel: 2495
Email: sarka.danacikova@fgu.cas.cz
Tel: 2739
Email: andrea.grigelova@fgu.cas.cz
Laborantka
Tel: 2549
Email: helena.havelkova@fgu.cas.cz
Doktorand
Tel: 2813
Email: david.kala@fgu.cas.cz
Laborant
Tel: 2549
Email: alex.kratina@fgu.cas.cz
Laborantka
Tel: 2571
Email: eva.lazkova@fgu.cas.cz
Vedoucí vědecký pracovník
Ředitel FGÚ (1995–2003)
Tel: 2549
Email: pavel.mares@fgu.cas.cz
Odborný pracovník VŠ ve VaV
Tel: 2495
Email: lukas.michal@fgu.cas.cz
Vědecký pracovník
Tel: 2273
Email: anna.mikulecka@fgu.cas.cz
Vědecký asistent
Email: alevtyna.morenko@fgu.cas.cz
Laborantka
Tel: 2535
Email: irinka.peneva@fgu.cas.cz
Tel: 2495
Email: antonin.posusta@fgu.cas.cz
Tel: 2495
Email: prysiazhniuk.yeva@fgu.cas.cz
Vědecký asistent
Tel: 2533
Email: lenka.roubalova@fgu.cas.cz
Odborný pracovník VaV
Tel: 2549
Email: sarka.ruzickova@fgu.cas.cz
Tel: 2549
Email: Zina.BenSalemova@fgu.cas.cz
Tel: 2495
Email: jan.svoboda2@fgu.cas.cz