Research of the Laboratory of Biological Rythms at the Institute of Physiology CAS reveals that biological clocks in the choroid plexus—the brain region responsible for cerebrospinal fluid production—are regulated not only by light but also by the timing of food intake. A study published in Cellular and Molecular Life Sciences demonstrates that these clocks can be rapidly reprogrammed by changing meal times, which in turn influences other important processes in the brain.
A mismatch between light exposure and meal timing can disrupt the brain’s internal environment and increase the risk of metabolic or neurodegenerative diseases. The study found that the choroid plexus is a unique brain structure that quickly reacts to both light and food intake timing, thus affecting brain protection and nourishment.
“Our results show that the choroid plexus is a key lifestyle sensor, integrating both light and dietary signals,” says Prof. Alena Sumová, head of the Laboratory of Biological Rhythms at the Institute of Physiology CAS.
Dočkal, T., Houdek, P., Semenovykh, K. et al. Feeding regime synchronizes circadian clock in choroid plexus – insight into a complex mechanism. Cell. Mol. Life Sci. 82, 247 (2025). IF = 6,2. doi:10.1007/s00018-025-05798-3
