
Klinicky užívané cévní protézy vyrobené z expandovaného polytetrafluoroethylénu (ePTFE) a z polyethylén tereftalátu (PET). Materiál protéz je vysoce hydrofobní a neumožňuje rekonstrukci přirozených buněčných vrstev cévní stěny.
What is a tissue replacement?
Irreversible damage to various vitally important tissues and organs, such as blood vessels, heart valves, bones, joints, cartilage or skin, is a serious and frequent consequence of the lifestyle of the contemporary civilized society. It is associated with various metabolic disorders and also with traffic, sport and industrial accidents. Hereditary disorders, wear and aging of the organism also play an adverse role.
When prevention, conservative treatment and surgical interventions fail, it is necessary to replace the damaged tissue. Autologous tissue, i.e. the patient's own tissue, is still considered to be the “gold standard” for tissue substitution. However, autologous tissue is usually available only in limited quantities, and acquiring the tissue burdens the patient with additional surgery and donor site morbidity. For this reason, increasing attention is being paid to artificial materials that serve as scaffolds for reconstructing the damaged tissue.
The main tasks of our laboratory are:
- to improve currently-used synthetic tissue replacements by introducing cell and other biological components
- to construct completely new replacements on the basis of synthetic materials and cells
- to achieve these two goals, we carry out studies on the molecular mechanisms of cell behavior on synthetic materials, such as the adhesion, growth, differentiation and viability of cells on artificial materials, together with studies on potential damage and immune activation.
Projects
Achievements
Tkáňově inženýrské konstrukty bývají obvykle osazovány diferencovanými buňkami, což však přináší určité nevýhody.
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Construction of the bilayer structure of human keratinocytes (the main cell type of the epidermis) and fibroblasts (the main cell type of the dermis) to nanofiber membranes of polylactide.
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Publications
Vondrášek; David - Hadraba; Daniel - Přibyl; J. - Eckhardt; Adam - Ošťádal; M. - Lopot; F. - Jelen; K. - Doubková; Martina - Knitlová; Jarmila - Novotný; T. - Janáček; Jiří
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Microstructural Analysis of Collagenous Structures in Relapsed Clubfoot Tissue
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Microscopy and Microanalysis. 2023; 29(1); 265-272
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IF = 2.8
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Táborská; Johanka - Blanquer; Andreu - Brynda; Eduard - Filová; Elena - Stiborová; Lenka - Jenčová; V. - Havlíčková; K. - Riedelová; Zuzana - Riedel; Tomáš
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PLCL/PCL dressings with platelet lysate and growth factors embedded in fibrin for chronic wound regeneration
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International Journal of Nanomedicine. 2023; 18(3 February); 595-610
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IF = 8.0
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Štěpánková; K. - Mareková; D. - Kubášová; K. - Sedláček; R. - Turnovcová; K. - Vacková; Irena - Kubinová; Šárka - Makovický; P. - Petrovičová; M. - Kwok; J. C. F. - Jendelová; P. - Urdzíková; L.
4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats
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International Journal of Molecular Sciences. 2023; 24(4)); 3799
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IF = 5.6
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Skvortsova; A. - Trelin; A. - Sedlář; Antonín - Erzina; M. - Trávníčková; Martina - Svobodová; Lucie - Kolská; Z. - Siegel; J. - Bačáková; Lucie - Švorčík; V. - Lyutakov; O.
SERS-CNN approach for non-invasive and non-destructive monitoring of stem cell growth on a universal substrate through an analysis of the cultivation medium
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Sensors and Actuators B - Chemical. 2023; 375(15 January)); 132812
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IF = 8.4
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Rogulska; Olena - Havelková; Jarmila - Petrenko; Yuriy
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Cryopreservation of Organoids
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Cryo-letters. 2023; 44(2); 65-75
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IF = 1.0
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Flis; A. - Trávníčková; Martina - Koper; F. - Knap; K. - Kasprzyk; W. - Bačáková; Lucie - Pamula; E.
Poly(octamethylene citrate) Modified with Glutathione as a Promising Material for Vascular Tissue Engineering
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Polymers. 2023; 15(5)); 1322
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IF = 5.0
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Filová; Elena - Šupová; Monika - Eckhardt; Adam - Vrbacký; Marek - Blanquer; Andreu - Trávníčková; Martina - Knitlová; Jarmila - Suchý; Tomáš - Rýglová; Šárka - Braun; Martin - Burdíková; Z. - Schätz; M. - Jenčová; V. - Lisnenko; M. - Běhálek; L. - Procházková; R. - Sedláček; R. - Kubasová; K. - Bačáková; Lucie
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Adipose-Derived Stem Cells in Reinforced Collagen Gel: A Comparison between Two Approaches to Differentiation towards Smooth Muscle Cells
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International Journal of Molecular Sciences. 2023; 24(6)); 5692
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IF = 5.6
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Zárubová; Jana - Hasani-Sadrabadi; M. M. - Norris; S. C. P. - Majedi; F. S. - Xiao; C. - Kasko; A. M. - Li; S.
Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells
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Small. 2022; 18(50)); 2203515
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IF = 13.3
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Zárubová; Jana - Hasani-Sadrabadi; M. M. - Dashtimoghadam; E. - Zhang; X. - Ansari; S. - Li; S. - Moshaverinia; A.
Engineered Delivery of Dental Stem-Cell-Derived Extracellular Vesicles for Periodontal Tissue Regeneration
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Advanced Healthcare Materials. 2022; 11(12)); 2102593
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IF = 10.0
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Zárubová; Jana - Hasani-Sadrabadi; M. M. - Ardehali; R. - Li; S.
Immunoengineering strategies to enhance vascularization and tissue regeneration
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Advanced Drug Delivery Reviews. 2022; 184(May)); 114233
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IF = 16.1
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Vackova; Irena - Vavřínová; E. - Musílková; Jana - Havlas; V. - Petrenko; Yuriy
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Hypothermic Storage of 3D Cultured Multipotent Mesenchymal Stromal Cells for Regenerative Medicine Applications
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Polymers. 2022; 14(13)); 2553
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IF = 5.0
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Swietek; Malgorzata Anna - Brož; Antonín - Kolodziej; A. - Hodan; Jiří - Tokarz; W. - Hlukhaniuk; Anna - Weselucha-Birczynska; A. - Bačáková; Lucie - Horák; Daniel
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Magnetic poly(.epsilon.-caprolactone)-based nanocomposite membranes for bone cell engineering
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Journal of Magnetism and Magnetic Materials. 2022; 563(1 December)); 169967
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IF = 2.7
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Novotný; T. - Eckhardt; Adam - Doubková; Martina - Knitlová; Jarmila - Vondrášek; David - Vanaskova; E. - Ošťádal; M. - Uhlík; J. - Bačáková; Lucie - Musílková; Jana
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The possible role of hypoxia in the affected tissue of relapsed clubfoot
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Scientific Reports. 2022; 12(1)); 4462
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IF = 4.6
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Neubertová; V. - Kasálková-Slepičková; N. - Vokatá; B. - Bačáková; Lucie - Švorčík; V. - Kolská; Z.
Influence of UV irradiation and subsequent chemical grafting on the surface properties of cellulose
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Cellulose. 2022; 29(3); 1405-1418
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IF = 5.7
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Němčáková; Ivana - Litvinec; Andrej - Mandys; V. - Potocký; Štěpán - Plencner; Martin - Doubková; Martina - Naňka; O. - Olejníčková; Veronika - Šaňková; Barbora - Bartoš; M. - Ukraintsev; E. - Babčenko; O. - Bačáková; Lucie - Kromka; Alexander - Rezek; B. - Sedmera; David
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Coating Ti6Al4V implants with nanocrystalline diamond functionalized with BMP-7 promotes extracellular matrix mineralization in vitro and faster osseointegration in vivo
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Scientific Reports. 2022; 12(1)); 5264
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IF = 4.6
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Molitor; M. - Trávníčková; Martina - Měšťák; O. - Christodoulou; P. - Sedlář; Antonín - Bačáková; Lucie - Lucchina; S.
Invited Response on: The Influence of Low and High-Negative-Pressure Liposuction and Different Harvesting Sites on the Viability and Yield of Adipocytes and Other Nucleated Cells
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Aesthetic Plastic Surgery. 2022; 46(Suppl.1); 35-36
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IF = 2.4
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Klimek; K. - Benko; A. - Vandrovcová; Marta - Trávníčková; Martina - Douglas; T. E. L. - Tarczynska; M. - Brož; Antonín - Gaweda; K. - Ginalska; G. - Bačáková; Lucie
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Biomimetic biphasic curdlan-based scaffold for osteochondral tissue engineering applications Characterization and preliminary evaluation of mesenchymal stem cell response in vitro
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Biomaterials Advances. 2022; 135(April)); 212724
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IF = 7.9
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Kacvinská; K. - Trávníčková; Martina - Vojtová; L. - Poláček; P. - Dorazilová; J. - Kohoutek; M. - Hlináková; K. - Pajorová; Julia - Tirpáková; Maria - Bačáková; Lucie
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Porous cellulose-collagen scaffolds for soft tissue regeneration: influence of cellulose derivatives on mechanical properties and compatibility with adipose-derived stem cells
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Cellulose. 2022; 29(15); 8329-8351
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IF = 5.7
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Chlupáč; Jaroslav - Matějka; R. - Koňařík; M. - Novotný; R. - Šimůnková; Z. - Mrázová; I. - Fabian; O. - Zapletal; M. - Pulda; Z. - Lipenský; J. F. - Štěpanovská; J. - Hanzálek; K. - Brož; Antonín - Novák; T. - Lodererová; A. - Voska; L. - Adla; T. - Froněk; J. - Rozkot; M. - Forostyak; S. - Kneppo; P. - Bačáková; Lucie - Pirk; J.
Vascular Remodeling of Clinically Used Patches and Decellularized Pericardial Matrices Recellularized with Autologous or Allogeneic Cells in a Porcine Carotid Artery Model
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International Journal of Molecular Sciences. 2022; 23(6)); 3310
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IF = 5.6
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Gabor; R. - Cvrček; L. - Doubková; Martina - Nehasil; V. - Hlinka; J. - Unucka; P. - Buřil; M. - Podepřelová; A. - Seidlerová; J. - Bačáková; Lucie
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Hybrid coatings for orthopaedic implants formed by physical vapour deposition and microarc oxidation
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Materials and Design. 2022; 219(July)); 110811
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IF = 8.4
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Dubišová; J. - Svobodová Buriánová; J. - Svobodová; Lucie - Makovický; P. - Martinez-Varea; N. - Cimpean; A. - Fawcett; J. W. - Kwok; J. C. F. - Kubinová; Šárka
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Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice
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Brain Research Bulletin. 2022; 181(Apr); 144-156
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IF = 3.8
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Dodda; J. M. - Azar; M. G. - Bělský; P. - Šlouf; Miroslav - Brož; Antonín - Bačáková; Lucie - Kadlec; J. - Remiš; T.
Biocompatible hydrogels based on chitosan; cellulose/starch; PVA and PEDOT:PSS with high flexibility and high mechanical strength
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Cellulose. 2022; 29(12); 6697-6717
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IF = 5.7
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Cvrček; L. - Krčil; J. - Musílková; Jana - Musílková; Veronika - Bačáková; Lucie - Nehasil; V. - Denk; F. - Čejka; Z.
Nanostructured TiNb coating improves the bioactivity of 3D printed PEEK
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Materials and Design. 2022; 224(Dec)); 111312
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IF = 8.4
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Bryan; A. - Wales; E. - Vedante; S. - Blanquer; Andreu - Neupane; D. - Mishra; S. - Bačáková; Lucie - Fujiwara; T. - Jennings; J. A. - Bumgardner; J. D.
Evaluation of Magnesium-Phosphate Particle Incorporation into Co-Electrospun Chitosan-Elastin Membranes for Skin Wound Healing
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Marine Drugs. 2022; 20(10)); 615
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IF = 5.4
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Brož; Antonín - Jirka; Ivan - Matějka; Roman - Štěpanovská; Jana - Doubková; Martina - Sajdl; P. - Drahokoupil; Jan - Volochanskyi; Oleksandr - Futóová; Terézia - Bačáková; Lucie
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Surface modifications of a silicalite film designed for coating orthopaedic implants
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Materials and Design. 2022; 224(Dec)); 111373
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IF = 8.4
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