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INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

Laboratory of Biomaterials and Tissue Engineering

Laboratory of Biomaterials and Tissue Engineering Klinicky užívané cévní protézy vyrobené z expandovaného polytetrafluoroethylénu (ePTFE) a z polyethylén tereftalátu (PET). Materiál protéz je vysoce hydrofobní a neumožňuje rekonstrukci přirozených buněčných vrstev cévní stěny.

What is a tissue replacement?

Irreversible damage to various vitally important tissues and organs, such as blood vessels, heart valves, bones, joints, cartilage or skin, is a serious and frequent consequence of the lifestyle of the contemporary civilized society. It is associated with various metabolic disorders and also with traffic, sport and industrial accidents. Hereditary disorders, wear and aging of the organism also play an adverse role.

When prevention, conservative treatment and surgical interventions fail, it is necessary to replace the damaged tissue. Autologous tissue, i.e. the patient's own tissue, is still considered to be the “gold standard” for tissue substitution. However, autologous tissue is usually available only in limited quantities, and acquiring the tissue burdens the patient with additional surgery and donor site morbidity. For this reason, increasing attention is being paid to artificial materials that serve as scaffolds for reconstructing the damaged tissue.

The main tasks of our laboratory are:

  • to improve currently-used synthetic tissue replacements by introducing cell and other biological components
  • to construct completely new replacements on the basis of synthetic materials and cells
  • to achieve these two  goals, we carry out studies on the molecular mechanisms of cell behavior on synthetic materials, such as the adhesion, growth, differentiation and viability of cells on artificial materials, together with studies on potential damage and immune activation.

Projects

Achievements

Skin tissue engineering

Construction of the bilayer structure of human keratinocytes (the main cell type of the epidermis) and fibroblasts (the main cell type of the dermis) to nanofiber membranes of polylactide. More

Publications

Zasońska; Beata Anna - Brož; Antonín - Šlouf; Miroslav - Hodan; Jiří - Petrovský; Eduard - Hlídková; Helena - Horák; Daniel . Magnetic superporous poly(2-hydroxyethyl methacrylate) hydrogel scaffolds for bone tissue engineering . Polymers. 2021; 13(11); 1-13); 1871 . IF = 4.329 [ASEP] [ doi ]
Vandrovcová; Marta - Tolde; Z. - Vaněk; Přemysl - Nehasil; V. - Doubková; Martina - Trávníčková; Martina - Drahokoupil; Jan - Buixaderas; Elena - Borodavka; Fedir - Nováková; J. - Bačáková; Lucie . Beta-Titanium Alloy Covered by Ferroelectric Coating-Physicochemical Properties and Human Osteoblast-Like Cell Response . Coatings. 2021; 11(2)); 210 . IF = 2.881 [ASEP] [ doi ]
Trávníčková; Martina - Kasálková-Slepičková; N. - Sedlář; Antonín - Molitor; M. - Musílková; Jana - Slepička; P. - Švorčík; V. - Bačáková; Lucie . Differentiation of adipose tissue-derived stem cells towards vascular smooth muscle cells on modified poly(L-lactide) foils . Biomedical Materials. 2021; 16(2)); 025016 . IF = 3.715 [ASEP] [ doi ]
Steinerová; Marie - Matějka; Roman - Štěpanovská; Jana - Filová; Elena - Staňková; Ľubica - Rysová; M. - Martinová; L. - Dragounová; Helena - Domonkos; Mária - Artemenko; Anna - Babchenko; Oleg - Otáhal; M. - Bačáková; Lucie - Kromka; Alexander . Human osteoblast-like SAOS-2 cells on submicron-scale fibers coated with nanocrystalline diamond films . Materials Science & Engineering C-Materials for Biological Applications. 2021; 121(Feb)); 111792 . IF = 7.328 [ASEP] [ doi ]
Sedlář; Antonín - Trávníčková; Martina - Matějka; Roman - Pražák; Šimon - Mészáros; Zuzana - Bojarová; Pavla - Bačáková; Lucie - Křen; Vladimír - Slámová; Kristýna . Growth Factors VEGF-A(165) and FGF-2 as Multifunctional Biomolecules Governing Cell Adhesion and Proliferation . International Journal of Molecular Sciences. 2021; 22(4)); 1843 . IF = 5.923 [ASEP] [ doi ]
Sedlář; Antonín - Trávníčková; Martina - Bojarová; Pavla - Vlachová; Miluše - Slámová; Kristýna - Křen; Vladimír - Bačáková; Lucie . Interaction between Galectin-3 and Integrins Mediates Cell-Matrix Adhesion in Endothelial Cells and Mesenchymal Stem Cells . International Journal of Molecular Sciences. 2021; 22(10)); 5144 . IF = 5.923 [ASEP] [ doi ]
Sailapu; S. K. - Blanquer; Andreu - Duch; M. - Esquivel; J. P. - Nogués; C. - Esteve; J. - Sabaté; N. Self-activated microbatteries to promote cell death through local electrical stimulation . Nano Energy. 2021; 83(May)); 105852 . IF = 17.881 [ASEP] [ doi ]
Kutová; A. - Staňková; Ľubica - Vejvodová; K. - Kvítek; O. - Vokatá; B. - Fajstavr; D. - Kolská; Z. - Brož; Antonín - Bačáková; Lucie - Švorčík; V. Influence of Drying Method and Argon Plasma Modification of Bacterial Nanocellulose on Keratinocyte Adhesion and Growth . Nanomaterials. 2021; 11(8)); 1916 . IF = 5.076 [ASEP] [ doi ]
Koper; F. - Świergosz; T. - Zaba; A. - Flis; A. - Trávníčková; Martina - Bačáková; Lucie - Pamula; E. - Bogdal; D. - Kasprzyk; W. P. Advancements in structure-property correlation studies of cross-linked citric acid-based elastomers from the perspective of medical application . Journal of Materials Chemistry B. 2021; 9(32); 6425-6440 . IF = 6.331 [ASEP] [ doi ]
Filová; Elena - Steinerová; Marie - Trávníčková; Martina - Knitlová; Jarmila - Musílková; Jana - Eckhardt; Adam - Hadraba; Daniel - Matějka; Roman - Pražák; Šimon - Štěpanovská; Jana - Kučerová; Johanka - Riedel; Tomáš - Brynda; Eduard - Lodererová; A. - Honsová; E. - Pirk; J. - Koňařík; M. - Bačáková; Lucie . Accelerated in vitro recellularization of decellularized porcine pericardium for cardiovascular grafts . Biomedical Materials. 2021; 16(2)); 025024 . IF = 3.715 [ASEP] [ doi ]

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People

Doc. MUDr. Lucie Bačáková, CSc.
Head of the Laboratory

Mgr. Elena Filová, Ph.D.
Deputy Head of the Laboratory

 

Ing. Irena Vacková, CSc.
Researcher

Věra Lisá, prom. biol.
Researcher
Mgr. Jana Racková (nee. Lišková), Ph.D.
Researcher (maternity leave)
RNDr. Jana Musílková, CSc.
Researcher
RNDr. Lubica Staňková (nee. Grausová), Ph.D.
Researcher
RNDr. Lucie Svobodová, Ph.D.
Researcher

Mgr. Antonín Brož, Ph.D.
Researcher

Ing. Markéta Zikmundová, Ph.D.
Postdoctoral Researcher

 

MUDr. Jaroslav Chlupáč, Ph.D.
Postdoctoral Researcher
Mgr. Ivana Němčáková (nee. Kopová), Ph.D.
Postdoctoral Researcher (maternity leave)
Ing. Jana Zárubová (nee. Havlíková), Ph.D.
Postdoctoral Researcher
Andreu Blanquer Jerez, Ph.D.
Postdoctoral Researcher
MUDr. Martina Trávníčková, Ph.D.
Postdoctoral Researcher
Mgr. Martina Doubková
PhD Student

Mgr. Júlia Pajorová
PhD Student

Mgr. Antonín Sedlář
PhD Student

Mgr. Šimon Pražák
PhD Student

 

Ing. Roman Matějka
Research Assistant

 

Ing. Jana Štěpanovská
Research Assistant

Jana Voborníková
Administrative Worker
Mgr. Jarmila Knitlová
Technician Biologist
Ivana Zajanová
Technician
  Bc. Kateřina Pokorná
pregradual student