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Laboratory of Developmental Cardiology

Laboratory of Developmental Cardiology

Ischemic heart disease is the main cause of mortality worldwide. We study cardiac tolerance to injury caused by acute oxygen deprivation from the molecular level to the whole organism using animal models. Our research is focused mainly on the study of mechanisms that underlie:

  • high cardiac tolerance to injury early ontogeny,
  • increased cardiac tolerance induced by adaptation to chronic hypoxia and regular exercise training,
  • permanent consequences of early developmental interventions for cardiac tolerance in adulthood,
  • and altered cardiac tolerance associated with various pathological states.

Further we study heart development with special emphasis on the cardiac conduction system. Our current research is focused on the following projects:

  • elucidating cardiac conduction system formation with phylogenetic approaches,
  • dynamic imaging methods for cardiac conduction system,
  • and development of new methods for quantitative analysis of fibrous structures to study branching patterns of the coronary vessels and cardiac conduction system.

13th conference New Frontiers in Basic Cardiovascular Research

Projects

Developmental aspects of cardiac ischemic tolerance

The immature heart is highly tolerant to ischemic injury, but chronic oxygen deficit during early ontogeny may have negative consequences that persist till adulthood. We study mechanisms responsible for developmental changes of cardiac ischemic tolerance. More

Cardiac ischemic tolerance in systemic hypertension

Systemic hypertension is a major risk factor of ischemic heart disease. However, it can also stimulate mechanisms that protect the heart against acute oxygen deprivation. We study the effects of various forms of hypertension on cardiac ischemic tolerance. More

Cardioprotective mechanism of chronic hypoxia

Prolonged exposure to hypoxic environment leads to adaptation which is associated with improved cardiac tolerance to acute oxygen deprivation. We study molecular mechanisms underlying the cardioprotective effects of chronic hypoxia on various manifestations of ischemic injury. More

Publications

Sedmera; David . HLHS: Power of the Chick Model . Journal of cardiovascular development and disease. 2022; 9(4)); 113 . IF = 4.415 [ASEP] [ doi ]
Sedmera; David . Mass cytometry imaging in physiology . Acta Physiologica. 2022; 235(2)); e13822 . IF = 7.523 [ASEP] [ doi ]
Olejníčková; Veronika - Kolesová; Hana - Bartoš; M. - Sedmera; David - Gregorovičová; Martina . The Tale-Tell Heart: Evolutionary tetrapod shift from aquatic to terrestrial life-style reflected in heart changes in axolotl (Ambystoma mexicanum) . Developmental Dynamics. 2022; 251(6); 1004-1014 . IF = 2.842 [ASEP] [ doi ]
Němčáková; Ivana - Litvinec; Andrej - Mandys; V. - Potocký; Štěpán - Plencner; Martin - Doubková; Martina - Naňka; O. - Olejníčková; Veronika - Šaňková; Barbora - Bartoš; M. - Ukraintsev; E. - Babčenko; O. - Bačáková; Lucie - Kromka; Alexander - Rezek; B. - Sedmera; David . Coating Ti6Al4V implants with nanocrystalline diamond functionalized with BMP-7 promotes extracellular matrix mineralization in vitro and faster osseointegration in vivo . Scientific Reports. 2022; 12(1)); 5264 . IF = 4.996 [ASEP] [ doi ]
Marković; Aleksandra - Tauchmannová; Kateřina - Šimáková; Miroslava - Mlejnek; Petr - Kaplanová; Vilma - Pecina; Petr - Pecinová; Alena - Papoušek; František - Liška; František - Šilhavý; Jan - Mikešová; Jana - Neckář; Jan - Houštěk; Josef - Pravenec; Michal - Mráček; Tomáš . Genetic Complementation of ATP Synthase Deficiency Due to Dysfunction of TMEM70 Assembly Factor in Rat . Biomedicines. 2022; 10(2)); 276 . IF = 4.757 [ASEP] [ doi ]
Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana . Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein . Biomedicines. 2022; 10(9)); 2066 . IF = 4.757 [ASEP] [ doi ]
Imig; J. D. - Červenka; L. - Neckář; Jan . Epoxylipids and soluble epoxide hydrolase in heart diseases . Biochemical Pharmacology. 2022; 195(Jan)); 114866 . IF = 6.100 [ASEP] [ doi ]
Tibenská; V. - Marvanová; A. - Elsnicová; B. - Hejnová; L. - Vebr; P. - Novotný; J. - Kolář; František - Nováková; Olga - Žurmanová; J.M. The cardioprotective effect persisting during recovery from cold acclimation is mediated by the beta(2)-adrenoceptor pathway and Akt activation . Journal of Applied Physiology. 2021; 130(3); 746-755 . IF = 3.880 [ASEP] [ doi ]
Pravenec; Michal - Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Mráček; Tomáš - Pecinová; Alena - Tauchmannová; Kateřina - Hüttl; M. - Malínská; H. - Kazdová; L. - Neckář; Jan - Kolář; František - Žurmanová; J. - Novotný; J. - Houštěk; Josef . Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat . Physiological Research. 2021; 70(Suppl.4); S471-S481 . IF = 2.139 [ASEP] [ doi ]
Petrovová; E. - Tomco; M. - Holovská; K. - Danko; J. - Krešáková; L. - Vdoviaková; K. - Simaiová; V. - Kolvek; F. - Horňáková; P. - Toth; T. - Zivcak; J. - Gal; P. - Sedmera; David - Luptáková; L. - Medvecký; L. PHB/CHIT Scaffold as a Promising Biopolymer in the Treatment of Osteochondral Defects-An Experimental Animal Study . Polymers. 2021; 13(8)); 1232 . IF = 4.967 [ASEP] [ doi ]
Ošťádal; Bohuslav - Ošťádalová; Ivana - Szárszoi; O. - Netuka; I. - Olejníčková; Veronika - Hlaváčková; Markéta . Sex-dependent effect of perinatal hypoxia on cardiac tolerance to oxygen deprivation in adults . Canadian Journal of Physiology and Pharmacology. 2021; 99(1); 1-8 . IF = 2.245 [ASEP] [ doi ]
Olejníčková; Veronika - Kočka; M. - Kvasilová; A. - Kolesová; Hana - Dziacky; A. - Gidor; T. - Gidor; L. - Šaňková; B. - Gregorovičová; Martina - Gourdie; R. G. - Sedmera; David . Gap Junctional Communication via Connexin43 between Purkinje Fibers and Working Myocytes Explains the Epicardial Activation Pattern in the Postnatal Mouse Left Ventricle . International Journal of Molecular Sciences. 2021; 22(5)); 2475 . IF = 6.208 [ASEP] [ doi ]
Neckář; Jan - Alánová; Petra - Olejníčková; Veronika - Papoušek; František - Hejnová; L. - Šilhavý; Jan - Behuliak; Michal - Bencze; Michal - Hrdlička; Jaroslav - Vecka; M. - Jarkovská; D. - Švíglerová; J. - Mistrová; E. - Štengl; M. - Novotný; J. - Ošťádal; Bohuslav - Pravenec; Michal - Kolář; František . Excess ischemic tachyarrhythmias trigger protection infarction in rats . Clinical science. 2021; 135(17); 2143-2163 . IF = 6.876 [ASEP] [ doi ]
Kolesová; Hana - Olejníčková; Veronika - Kvasilová; A. - Gregorovičová; Martina - Sedmera; David . Tissue clearing and imaging methods for cardiovascular development . iScience. 2021; 24(4)); 102387 . IF = 6.107 [ASEP] [ doi ]
Kindernay; L. - Farkašová; V. - Neckář; Jan - Hrdlička; Jaroslav - Ytrehus; K. - Ravingerová; T. Impact of Maturation on Myocardial Response to Ischemia and the Effectiveness of Remote Preconditioning in Male Rats . International Journal of Molecular Sciences. 2021; 22(20)); 11009 . IF = 6.208 [ASEP] [ doi ]

People

RNDr. Jan Neckář, Ph.D.
Head of the Laboratory
   Prof. RNDr. František Kolář, CSc.
Deputy Head of the Laboratory
Prof. MUDr. David Sedmera, DSc.
Senior Researcher
Prof. MUDr. Bohuslav Ošťádal, DrSc.
Senior Researcher
MUDr. Ivana Ošťádalová, CSc.
Senior Researcher
Ing. František Papoušek, CSc.
Senior Researcher
RNDr. Markéta Hlaváčková, Ph.D.
Senior Researcher
  Olga Nováková
Senior Researcher
RNDr. Petra Alánová, Ph.D.
Postdoctoral Fellow
RNDr. Martina Gregorovičová, Ph.D.
Postdoctoral Fellow
  Mgr. Petra Kolesová, Ph.D.
Postdoctoral Fellow
MVDr. Veronika Olejníčková, Ph.D.
Postdoctoral Fellow

RNDr. Kristýna Holzerová, Ph.D.
Postdoctoral Fellow

Mgr. Jaroslav Hrdlička, Ph.D.
Postdoctoral Fellow
Mgr. Daniel Benák
PhD Student
Mgr. Barbora Opletalová
PhD Student
 

MUDr. Tereza Vavříková
PhD Student

Ing. Miloslava Marková
Technician
Milana Pešková
Technician
Jarmila Svatůňková
Technician