Metabolic syndrome is defined as the co-occurrence of several risk factors for type 2 diabetes and cardiovascular disease: mainly obesity, insulin resistance, high triglyceride and LDL cholesterol levels, and hypertension. These risk factors are determined by many genes with small effects and their interactions with environmental factors. Genome-wide association studies have so far revealed only a small fraction of the heritability of complex pathophysiological traits in humans. Thus, analyses of animal models of human complex diseases may represent a useful alternative. The department's research is focused on the following projects:
- Uncovering genes regulating hemodynamic and metabolic traits in the SHR strain.
- Analysis of the mechanisms underlying the development of salt sensitive hypertension.
Projects
Publications
Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Marková; I. - Malínská; H. - Hüttl; M. - Kazdová; L. - Kazantsev; D. - Mancini; M. - Novotný; J. - Pravenec; Michal
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CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study
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PLoS ONE. 2023; 18(4)); e0283276
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IF = 3.7
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doi
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Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Malínská; H. - Marková; I. - Hüttl; M. - Miklánková; D. - Kazdová; L. - Vrbacký; Marek - Pecinová; Alena - Mráček; Tomáš - Pravenec; Michal
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Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome
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Metabolites. 2023; 13(2)); 192
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IF = 4.1
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doi
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Kurtz; T. W. - Morris Jr.; R. C. - Pravenec; Michal - Lujan; H. L. - DiCarlo; S. E.
Hypertension in Primary Aldosteronism Is Initiated by Salt-Induced Increases in Vascular Resistance With Reductions in Cardiac Output
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Hypertension. 2023; 80(5); 1077-1091
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IF = 8.3
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doi
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Hüttl; M. - Marková; I. - Miklánková; D. - Zapletalová; I. - Kujal; P. - Šilhavý; Jan - Pravenec; Michal - Malínská; H.
Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model
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Frontiers in Pharmacology. 2023; 14(3 Apr)); 1117683
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IF = 5.6
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doi
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Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Liška; František - Kubovčiak; Jan - Sticová; E. - Pravenec; Michal
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Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension
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Biomedicines. 2022; 10(2)); 376
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IF = 4.7
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doi
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Senko; A. N. - Overall; R. W. - Šilhavý; Jan - Mlejnek; Petr - Malínská; H. - Hüttl; M. - Marková; I. - Fabel; K. S. - Lu; L. - Stuchlík; Aleš - Williams; R. W. - Pravenec; Michal - Kempermann; G.
Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose
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PLoS Genetics. 2022; 18(4)); e1009638
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IF = 4.5
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doi
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Marković; Aleksandra - Tauchmannová; Kateřina - Šimáková; Miroslava - Mlejnek; Petr - Kaplanová; Vilma - Pecina; Petr - Pecinová; Alena - Papoušek; František - Liška; František - Šilhavý; Jan - Mikešová; Jana - Neckář; Jan - Houštěk; Josef - Pravenec; Michal - Mráček; Tomáš
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Genetic Complementation of ATP Synthase Deficiency Due to Dysfunction of TMEM70 Assembly Factor in Rat
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Biomedicines. 2022; 10(2)); 276
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IF = 4.7
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doi
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Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana
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Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
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Biomedicines. 2022; 10(9)); 2066
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IF = 4.7
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doi
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Lusk; R. - Hoffman; P.L. - Mahaffey; S. - Rosean; S. - Smith; H. - Šilhavý; Jan - Pravenec; Michal - Tabakoff; B. - Saba; L. M.
Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel
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Frontiers in genetics. 2022; 13(Mar 15)); 821026
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IF = 3.7
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doi
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Kurtz; T. W. - Pravenec; Michal - DiCarlo; S. E.
Do conclusions drawn from spot urine sodium measurements agree with the conclusions drawn from the 24-h urine measurements?
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Journal of Hypertension. 2022; 40(11); 2316-2317
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IF = 4.9
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[
doi
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Kurtz; T. W. - Pravenec; Michal - DiCarlo; S. E.
Will Food and Drug Administration Guidance to Reduce the Salt Content of Processed Foods Reduce Salt Intake and Save Lives?
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Hypertension. 2022; 79(4); 809-812
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IF = 6.0
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[
doi
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Kurtz; T. W. - Pravenec; Michal - DiCarlo; S. E.
Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension
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Clinical science. 2022; 136(8); 599-620
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IF = 8.3
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[
doi
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Dahale; S. - Ruiz-Orera; J. - Šilhavý; Jan - Hübner; N. - van Heesch; S. - Pravenec; Michal - Atanur; S. S.
Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension
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Life Science Alliance. 2022; 5(4)); e202101234
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IF = 4.4
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[
doi
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Witte; F. - Ruiz-Orera; J. - Mattioli; C. C. - Blachut; S. - Adami; E. - Schulz; J. F. - Schneider-Lunitz; V. - Hummel; O. - Patone; G. - Mücke; M. B. - Šilhavý; Jan - Heinig; M. - Bottolo; L. - Sanchis; D. - Vingron; M. - Chekulaeva; M. - Pravenec; Michal - Hubner; N. - van Heesch; S.
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion
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Genome Biology. 2021; 22(1)); 191
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IF = 18.010
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[
doi
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Pravenec; Michal - Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Mráček; Tomáš - Pecinová; Alena - Tauchmannová; Kateřina - Hüttl; M. - Malínská; H. - Kazdová; L. - Neckář; Jan - Kolář; František - Žurmanová; J. - Novotný; J. - Houštěk; Josef
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Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat
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Physiological Research. 2021; 70(Suppl.4); S471-S481
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IF = 2.139
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[
doi
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Neckář; Jan - Alánová; Petra - Olejníčková; Veronika - Papoušek; František - Hejnová; L. - Šilhavý; Jan - Behuliak; Michal - Bencze; Michal - Hrdlička; Jaroslav - Vecka; M. - Jarkovská; D. - Švíglerová; J. - Mistrová; E. - Štengl; M. - Novotný; J. - Ošťádal; Bohuslav - Pravenec; Michal - Kolář; František
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Excess ischemic tachyarrhythmias trigger protection infarction in rats
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Clinical science. 2021; 135(17); 2143-2163
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IF = 6.876
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[
doi
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Mihola; Ondřej - Landa; Vladimír - Pratto; F. - Brick; K. - Kobets; Tetyana - Kusari; Fitore - Gašić; Srdjan - Smagulova; F. - Grey; C. - Flachs; Petr - Gergelits; Václav - Třešňák; Karel - Šilhavý; Jan - Mlejnek; Petr - Camerini-Otero; R.D. - Pravenec; Michal - Petukhova; G.V. - Trachtulec; Zdeněk
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Rat PRDM9 shapes recombination landscapes; duration of meiosis; gametogenesis; and age of fertility
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BMC BIOLOGY. 2021; 19(1)); 86
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IF = 7.364
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doi
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Kurtz; T. W. - DiCarlo; S. E. - Pravenec; Michal - Morris Jr.; R. C.
No evidence of racial disparities in blood pressure salt sensitivity when potassium intake exceeds levels recommended in the US dietary guidelines
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American Journal of Physiology-Heart and Circulatory Physiology. 2021; 320(5); H1903-H1918
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IF = 5.125
[ASEP]
[
doi
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Křížová; J. - Hůlková; M. - Čapek; V. - Mlejnek; Petr - Šilhavý; Jan - Tesařová; M. - Zeman; J. - Hansíková; H.
Microarray and qPCR Analysis of Mitochondrial Metabolism Activation during Prenatal and Early Postnatal Development in Rats and Humans with Emphasis on CoQ(10) Biosynthesis
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BIOLOGY-BASEL. 2021; 10(5)); 418
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IF = 5.168
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doi
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Krijt; J. - Sokolová; J. - Šilhavý; Jan - Mlejnek; Petr - Kubovčiak; Jan - Liška; František - Malínská; H. - Hüttl; M. - Marková; I. - Křížková; M. - Stipanuk; M. H. - Křížek; T. - Ditroi; T. - Nagy; P. - Kožich; V. - Pravenec; Michal
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High Cysteine Diet Reduces Insulin Resistance in SHR-CRP Rats
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Physiological Research. 2021; 70(5); 687-700
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IF = 2.139
[ASEP]
[
doi
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Junková; K. - Mirchi; L. F. - Chylíková; B. - Janků; M. - Šilhavý; Jan - Hüttl; M. - Marková; I. - Miklánková; D. - Včelák; J. - Malínská; H. - Pravenec; Michal - Šeda; O. - Liška; František
.
Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation
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Nutrients. 2021; 13(5)); 1462
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IF = 6.706
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[
doi
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Šilhavý; Jan - Malínská; H. - Hüttl; M. - Marková; I. - Oliyarnyk; O. - Mlejnek; Petr - Šimáková; Miroslava - Liška; František - Kazdová; L. - Moravcová; R. - Novotný; J. - Pravenec; Michal
.
Downregulation of the Glo1 Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats
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ANTIOXIDANTS. 2020; 9(12)); 1179
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IF = 6.312
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doi
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Kurtz; T. W. - Pravenec; Michal - DiCarlo; S. E.
Strategies Are Needed to Prevent Salt-Induced Hypertension That Do Not Depend on Reducing Salt Intake
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American Journal of Hypertension. 2020; 33(2); 116-118
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IF = 2.689
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[
doi
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Tan, A. L. M. - Langley, S. R. - Tan, Ch. F. - Chai, J. F. - Khoo, CH. M. - Leow, M. K.-S. - Khoo, E. Y. H. - Moreno-Moral, A. - Pravenec, Michal - Rotival, M. - Sadananthan, S. A. - Velan, S. S. - Venkataraman, K. - Chong, Y. S. - Lee, Y. S. - Sim, X. - Stunkel, W. - Liu, M. H. - Tai, E. S. - Petretto, E.
Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in Singapore
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Journal of Clinical Endocrinology and Metabolism 2019, 104(2), 465-486
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IF = 5.399
[ASEP]
[
doi
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Svoboda; Petr - Křížová; E. - Šestáková; Š. - Vápenková; K. - Knejzlík; Z. - Rimpelová; S. - Rayová; D. - Volfová; N. - Křížová; I. - Rumlová; M. - Sýkora; D. - Kizek; R. - Haluzík; M. - Zídek; Václav - Zídková; J. - Škop; V.
Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells; and its inhibition slows cell growth
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Journal of Biological Chemistry. 2019; 294(22); 8676-8689
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IF = 4.238
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[
doi
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Olson; E. - Pravenec; Michal - Landa; Vladimír - Koh-Tan; H.H.C. - Dominiczak; A. F. - McBride; M. W. - Graham; D.
Transgenic overexpression of glutathione S-transferase mu-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat
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Journal of Hypertension. 2019; 37(5); 985-996
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IF = 4.171
[ASEP]
Nedvědová, I. - Kolář, D. - Neckář, Jan - Kalous, M. - Pravenec, Michal - Šilhavý, Jan - Korenková, Vlasta - Kolář, František - Žurmanová, J.M.
Cardioprotective Regimen of Adaptation to Chronic Hypoxia Diversely Alters Myocardial Gene Expression in SHR and SHR-mt(BN) Conplastic Rat Strains
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Frontiers in Endocrinology 2019, 9(Jan 22)), 809
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IF = 3.644
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[
doi
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Morris Jr., R. C. - Pravenec, Michal - Šilhavý, Jan - DiCarlo, S. E. - Kurtz, T. W.
Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure
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Hypertension 2019, 73(5), 1042-1048
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IF = 7.713
[ASEP]
[
doi
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Kurtz, T. W. - DiCarlo, S. E. - Pravenec, Michal - Morris, R. C.
Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity
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Hypertension Research 2019, 42(1), 6-18
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IF = 2.941
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[
doi
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Chen; H. - Moreno-Moral; A. - Pesce; F. - Devapragash; N. - Mancini; M. - Heng; E. L. - Rotival; M. - Srivastava; P. K. - Harmston; N. - Shkura; K. - Rackham; O. J. L. - Yu; W.-P. - Sun; X. M. - Tee; N. G. Z. - Tan; E. L. S. - Barton; P. J. R. - Felkin; L. E. - Lara-Pezzi; E. - Angelini; G. - Beltrami; C. - Pravenec; Michal - Schafer; S. - Bottolo; L. - Hubner; N. - Emanueli; C. - Cook; S. A. - Petretto; E.
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
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Nature Communications. 2019; 10(Aug 9)); 3616
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IF = 12.121
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[
doi
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Šilhavý, Jan - Mlejnek, Petr - Šimáková, Miroslava - Vaněčková, Ivana - Behuliak, Michal - Kuda, Ondřej - Sticová, E. - Jirsa, M. - Pravenec, Michal
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Acute toxic effects of telmisartan in spontaneously hypertensive rats fed a high fructose diet
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Physiological Research 2018, 67(6), 851-856
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IF = 1.701
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Šilhavý, Jan - Krijt, J. - Sokolová, J. - Zídek, Václav - Mlejnek, Petr - Šimáková, Miroslava - Škop, V. - Trnovská, J. - Oliyarnyk, O. - Marková, I. - Hüttl, M. - Malínská, H. - Kazdová, L. - Liška, F. - Kožich, V. - Pravenec, Michal
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Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats
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Physiological Research 2018, 67(4), 657-662
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IF = 1.701
[ASEP]
Pravenec, Michal - Saba, L. M. - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šilhavý, Jan - Šimáková, Miroslava - Strnad, Hynek - Trnovská, J. - Škop, V. - Hüttl, M. - Marková, I. - Oliyarnyk, O. - Malínská, H. - Kazdová, L. - Smith, H. - Tabakoff, B.
Systems genetic analysis of brown adipose tissue function
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Physiological Genomics 2018, roč. 50, 1, p. 52-66
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IF = 2.581
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[
doi
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Pravenec, Michal - Leung, K.-Y. - Zídek, Václav - Mlejnek, Petr - Šimáková, Miroslava - Šilhavý, Jan - Kožich, V. - Greene, N. D. E.
Genetically Determined Folate Deficiency Is Associated With Abnormal Hepatic Folate Profiles in the Spontaneously Hypertensive Rat
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Physiological Research 2018, roč. 67, 3, p. 417-422
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IF = 1.701
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Nedvědová, I. - Kolář, D. - Elsnicová, B. - Horníková, D. - Novotný, J. - Kalous, M. - Pravenec, Michal - Neckář, Jan - Kolář, František - Žurmanová, J.M.
Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia
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Physiological Genomics 2018, roč. 50, 7, p. 532-541
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IF = 2.581
[ASEP]
[
doi
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