Laboratory of Genetics of Model Diseases

Laboratory of Genetics of Model Diseases - bg 3

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Laboratory of Genetics of Model Diseases - stazeny soubor

About the Laboratory

Metabolic syndrome is defined as the co-occurrence of several risk factors for type 2 diabetes and cardiovascular disease: mainly obesity, insulin resistance, high triglyceride and LDL cholesterol levels, and hypertension. These risk factors are determined by many genes with small effects and their interactions with environmental factors. Genome-wide association studies have so far revealed only a small fraction of the heritability of complex pathophysiological traits in humans. Thus, analyses of animal models of human complex diseases may represent a useful alternative. The department’s research is focused on the following projects:

  • Uncovering genes regulating hemodynamic and metabolic traits in the SHR strain.
  • Analysis of the mechanisms underlying the development of salt sensitive hypertension.

Publications

Němečková; I. - Eissazadeh; S. - Rathouská Urbánková; J. - Šilhavý; Jan - Malínská; H. - Pravenec; Michal - Nachtigal; P. Transgenic human C-reactive protein affects oxidative stress but not inflammation biomarkers in the aorta of spontaneously hypertensive rats. BMC Cardiovascular Disorders. 2024; 24(1); 211.

IF = 2.0

Čížková; D. - Žurmanová; J.M. - Geryková; L. - Kouvelas; A. - Heleš; M. - Elsnicová; B. - Galatík; F. - Šilhavý; Jan - Pravenec; Michal - Mokrý; J. Nestin expression in intact and hypertrophic myocardium of spontaneously hypertensive rats during aging. Journal of Muscle Research and Cell Motility. 2024; 45(2); 41-51.

IF = 1.8

Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Marková; I. - Malínská; H. - Hüttl; M. - Kazdová; L. - Kazantsev; D. - Mancini; M. - Novotný; J. - Pravenec; Michal CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study. PLoS ONE. 2023; 18(4)); e0283276.

IF = 3.7

Kurtz; T. W. - Morris Jr.; R. C. - Pravenec; Michal - Lujan; H. L. - DiCarlo; S. E. Hypertension in Primary Aldosteronism Is Initiated by Salt-Induced Increases in Vascular Resistance With Reductions in Cardiac Output. Hypertension. 2023; 80(5); 1077-1091.

IF = 8.3

Gunia; Anna - Moraresku; Sofiia - Janča; R. - Ježdík; P. - Kalina; A. - Hammer; J. - Marusič; P. - Vlček; Kamil The brain dynamics of visuospatial perspective-taking captured by intracranial EEG. Neuroimage. 2024; 285(January); 120487.

IF = 5.7

Kaupová Drtikolová; S. - Brůžek; J. - Hadrava; J. - Mikšík; I. - Morvan; Marine - Poláček; Lumír - Půtová; L. - Velemínský; P. Early life histories at medieval Mikulcice (ninth-tenth centuries AD; Czechia) based on carbon and nitrogen profiles of tooth dentine. Archaeological and Anthropological Sciences. 2024; 16(1); 16.

IF = 2.2

People

Head of Laboratory

Vedoucí oddělení OBK, Vědecký pracovník
Tel: 2820
Email: petr.mlejnek@fgu.cas.cz
Vedoucí oddělení
Tel: 2297
Email: michal.pravenec@fgu.cas.cz
Vedoucí oddělení
Tel: 2153
Email: jan.silhavy@fgu.cas.cz

Deputy Head of Laboratory

Laboratory staff

Tel: 2820
Email: alena.musilova@fgu.cas.cz
Ošetrovatelka laboratorních zvířat
Email: katerina.pavelkova@fgu.cas.cz
Vědecký pracovník
Tel: 2735
Email: miroslava.simakova@fgu.cas.cz