Laboratory of Genetics of Model Diseases
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About the Laboratory
Metabolic syndrome is defined as the co-occurrence of several risk factors for type 2 diabetes and cardiovascular disease: mainly obesity, insulin resistance, high triglyceride and LDL cholesterol levels, and hypertension. These risk factors are determined by many genes with small effects and their interactions with environmental factors. Genome-wide association studies have so far revealed only a small fraction of the heritability of complex pathophysiological traits in humans. Thus, analyses of animal models of human complex diseases may represent a useful alternative. The department’s research is focused on the following projects:
- Uncovering genes regulating hemodynamic and metabolic traits in the SHR strain.
- Analysis of the mechanisms underlying the development of salt sensitive hypertension.
Projects
Publications
Němečková; I. - Eissazadeh; S. - Rathouská Urbánková; J. - Šilhavý; Jan - Malínská; H. - Pravenec; Michal - Nachtigal; P. Transgenic human C-reactive protein affects oxidative stress but not inflammation biomarkers in the aorta of spontaneously hypertensive rats. BMC Cardiovascular Disorders. 2024; 24(1); 211.
IF = 2.0
Čížková; D. - Žurmanová; J.M. - Geryková; L. - Kouvelas; A. - Heleš; M. - Elsnicová; B. - Galatík; F. - Šilhavý; Jan - Pravenec; Michal - Mokrý; J. Nestin expression in intact and hypertrophic myocardium of spontaneously hypertensive rats during aging. Journal of Muscle Research and Cell Motility. 2024; 45(2); 41-51.
IF = 1.8
Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Marková; I. - Malínská; H. - Hüttl; M. - Kazdová; L. - Kazantsev; D. - Mancini; M. - Novotný; J. - Pravenec; Michal CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study. PLoS ONE. 2023; 18(4)); e0283276.
IF = 3.7
Stanić; Sara - Bardová; Kristina - Janovská; Petra - Rossmeisl; Martin - Kopecký; Jan - Zouhar; Petr Prolonged FGF21 treatment increases energy expenditure and induces weight loss in obese mice independently of UCP1 and adrenergic signaling. Biochemical Pharmacology. 2024; 221(March); 116042.
IF = 5.8
Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Liška; František - Malínská; H. - Marková; I. - Hüttl; M. - Miklánková; D. - Mušálková; D. - Stránecký; V. - Kmoch; S. - Sticová; E. - Vrbacký; Marek - Mráček; Tomáš - Pravenec; Michal Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat. Physiological Genomics. 2024; 56(1); 65-73.
IF = 4.6